Hygetropin HGH 8iu

ONE ORDER UNIT INCLUDES:
5 VIALS CONTAINING 8IU EACH
TOTAL IU PER ONE ORDER UNIT:  40IU

WHAT IS HYGETROPIN
Hygetropin is a Human Growth Hormone (hGH) Somatropin produced with recombinant DNA technology identical to the body naturally produced HGH. Hygetropin is a synthetic 191 amino acid sequence identical to the human growth hormone produced naturally in the body by the pituitary.

COMPOSITION
Hygetropin is a sterile, while, lyophilized powder intended for subcutaneous administration after reconstitution with Bacteriostatic Water for Injection.

INDICATIONS
Some of the conditions for which Hygetropin is being used for :

• GHD - Growth Hormone Deficiency - In children treatment of growth failure due to the lack of adequate endogenous GH secretion.



• GHD/AGHD - Adult Growth Hormone Deficiency, in adults with endogenous GH deficiency due to a medical condition or aging.



• Anti-Aging - To improve metabolism, fat-free mass, mood, skin, sleep and general well being.



• Growth failure associated with chronic renal insufficiency up to the time of renal transplantation.



• Short stature associated with Turner syndrome.



• Patients with severe catabolic states such as surgery, trauma, burns or organ failure, to promote the protein synthesis.



• Treatment of congestive heart failure and osteoporosis.



• To decrease body fat & cellulite.



• To improve skin texture and appearance (decreased wrinkles).



• To gain lean muscle mass.



• Other conditions as determined by a physician.

DOSAGE
Dosage is individual and should be determined only by a licensed physician based on condition, purpose and body weight.
Your doctor should determine the daily dosage appropriate for your condition, it could be as little as 1-2iu per day such as those usually prescribed for anti-aging purposes or as much as 8-16iu a day usually prescribed in more acute cases. Depanding on the dosage you take, your doctor may decide if you should split the dosage to more than one injection per day or otherwise inject only once a day.

General dosages:

• Growth disturbance due to insufficient secretion of growth hormone in children: Generally a dose of 0.07-0.1 IU/kg body weight per day is recommended. Even higher doses have been used.
• Gonadal dysgenesis (Turner's syndrome): Generally a dose of 0.14 IU/kg body weight per day is recommended.
• Chronic renal insufficiency: Generally a dose of 0.14 IU/kg body weight per day is recommended.
• Growth hormone deficiency in adults: Generally an initial dose for about four weeks of 0.0178 IU/kg body weight per day is recommended. The daily dose should then be modulated according to the side effects of the patients as well as determination of Insulin like Growth Factor-l (IGF-I) in serum as guidance.
• For severe burns or multiple injuries: Generally an initial dose of 8IU/day followed by 16IU/day after patients' blood glucose level is stabilized is recommended. Typical treatment starts in 6 days after burns or injuries and treatment length is about 15-20 days.
• For major operations: Generally a dose of 12IU/day for a period of 10 days is recommended. Typical treatment starts in 2-3 days after operations.

OVERDOSE
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include headache, nausea, vomiting and bloating or swelling of ankles, feet, or hands.

CONTRAINDICATIONS
Hygetropin must not be used when there is any evidence of activity of brain tumor. Intracranial lesions must be inactive and antitumour therapy completed prior to starting therapy. Hygetropin should not be used for growth promotion in children with closed epiphyses.

STORAGE
Before Reconstitution: Hygetropin must be kept refrigerated and stored at 2 - 8C. Avoid freezing the vials of Hygetropin, this will damage the GH. After Reconstitution: Vial contents are stable for 72 hours when reconstituted with Bacteriostatic Water for Injection and stored at 2 - 8C. Avoid freezing the reconstituted vial of Hygetropin, doing so will damage the GH. Pre-reconstituted Hygetropin will maintain potency if stored in room temperature 25c for up to one month, however keep refrigerated whenever possible. Expiration dates are stated on the labels. Always keep away from direct light.

INSTRUCTIONS FOR USE & HANDLING

Releasing the vacuum inside vial
Hygetropin vials are air-vacuumed to preserve the powder. Before using an Hygetropin hGH vial you should let all air out of the vial, this should be done only once for every new vial to be used. It can be done by inserting a bare needle or one attached to a syringe into the vial to let all air get sucked out of the vial.
Reconstitution
Hygetropin should be used with sterile bacteriostatic water for injection. The water acts as a solvent to dissolve the powder inside the vial and turn it into an injectable solution. Use a new sterile syringe (pin width should be 19G-27G) to pull solvent into syringe (1ml of water or less) Inject the water very slowly in a controlled manner to the side of the vial and let the water slide down the bottom of the vial. Do not push the water directly onto the GH powder! Doing so will damage it. Gently dissolve the drug with a slow, swirling motion. Do not shake vigorously, or the active ingredient might denature. Inspect to see if there is still powder at the bottom of the vial, you may need to let the vial in room temperature for a few minutes in order for powder to dissolve completely.
Injection
Using an insulin syringe gently withdraw from the vial the desired dose to be injected and release any unwanted air from the syringe. Hygetropin should be injected subcutaneously by preferred areas are stomach or upper thighs. Wash hands and rub skin with alcohol pad, with one hand pinch 2" inch fold of skin between your thumb and index finger. Hold insulin the syringe with the other hand. Insert the needle at about 90 degrees angle to the pinched skin. Gently pull back the plunger to check for blood. If blood enters the solution do not inject, withdraw the needle and start again at a new injection site. Push the plunger gently to inject, when plunger is all the way down, remove the syringe gently and lightly hold an alcohol pad on the injection site. Do not rub the area. Dispose of syringe, needles and alchohol pads and always use new ones for each injection. The injection site should be varied to prevent lipoathrophy.